Osmium(VI) complexes as a new class of potential anti-cancer agents.
نویسندگان
چکیده
A nitridoosmium(VI) complex [Os(VI)(N)(sap)(OH(2))Cl] (H(2)sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5'-guanosine monophosphate.
منابع مشابه
Synthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands.
A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 7 شماره
صفحات -
تاریخ انتشار 2011